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These insights are crucial for understanding the roles and mechanisms of macrophages within the immune microenvironment.139,140,141 Single-cell sequencing analysis allows for high-resolution analysis of gene and protein expression in macrophages, revealing unique subpopulations and functional characteristics in various locations, such as the liver, lungs, kidneys, brain, etc.134,135,136,137,138 Additionally, researchers could use a range of softwares or websites(such as CellChat, CellPhoneDB, etc.) to analyze single-cell sequencing data and construct interaction networks between different cell populations in the immune microenvironment, which could be applied for the identification of interactions between macrophages and other microenvironmental cells, as well as related secreted factors, ligands/receptors, and signaling pathways. 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