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The C′ peak can be used for creatinine detection by narrowing the potential window, and the detection limit found by these authors was 35 μM, and the concentration range was 0–10 mM (Fig. 5ii–iv). Ngamchuea et al. employed cyclic voltammetry to characterize the creatinine detection using CuSO4. This behavior was attributed to creatinine molecules which are absorbed in the active sites of the polymeric matrix (Fig. 4a). Reddy et al. employed impedance to corroborate the creatinine detection on molecularly imprinted polymer (MIP)-based non-enzymatic electrodes, comparing the results with a non-imprinted polymer electrode.39 The Nyquist diagrams showed that the non-imprinted polymer electrode did not present the semicircle of charge transfer resistance; the molecular imprinted polymer did with a value of 507 Ω. The creatinine concentration range was from 0 to μM, and the detection limit was found to be 11 μM. 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