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It is important to bear in mind that there are contrasting findings, and beneficial associations of T with cardiovascular outcomes may be less evident in healthier middle-aged men. There is a suggestion that T treatment which achieves normal T concentrations may relate to lower risk of cardiovascular events and mortality. In summary, earlier findings associating T prescriptions with adverse cardiovascular outcomes were echoed in a more recent study. However, the authors of that study noted that the available RCT data might have had inadequate power to detect an increased risk. They may contain ingredients not mentioned in the label and the strength and concentration of the components may not also match the information on the label. The period for which the effects of the FDA-approved prescription drugs for ED last varies; sildenafil effects last for about 4 hours, vardenafil lasts for about 6 hours, and tadalafil effects last for up to 36 hours with one dose. 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