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Thus, this systematic review and meta-analysis evaluated clinical trials up to 2020 that have assessed the effect of Ashwagandha (Withania somnifera) supplementation on physical performance (considering as main variables the muscle strength, VO2max, muscle fatigue, tiredness, and physical recovery (i.e., pain, inflammatory status, and sleep quality)) in healthy individuals. Moreover, no comprehensive systematic review with Bayesian meta-analysis has been carried out on clinical trials that have investigated the effect of the aqueous extract of the root of this plant on the different physical capacities and variables related to physical performance in healthy adult subjects. 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