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Dr. Smith also notes that the use of synthetic ingredients or low-quality natural ingredients can have negative side effects and reduce the effectiveness of the product. CBD, or cannabidiol, is a non-psychoactive compound found in hemp plants, which has been shown to have potential health benefits, including pain relief, anxiety reduction, and improved sleep quality. Everything About Hempderived Cbd Gummies Previous cross-sectional analyses have found at least one reported side effect in 29–59% of patients using CBD for different indications which is in concordance with our findings (41%) (Corroon & Phillips, 2018; Devitt, 2019; Moltke & Hindocha, 2021). Recently, the World Health Organization released a critical review on CBD and found it is generally well tolerated with a good safety profile and does not have abuse potential (Expert Committee on Drug Dependence, 2018). Cannabidiol could have unwanted side effects and/or interactions with other medications. 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