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In addition, 24 million of these patients have limited activity as a result of their arthritis (Arthritis | CDC, n.d.). Few studies have looked specifically at arthritis to determine the subjective benefits of CBD use. Specifically, basic science studies have depicted that the endocannabinoid system (ECS) is prevalent within the synovium and can regulate inflammation and nociception in both humans and animal synovial joints (Hammell et al., 2016; Malfait et al., 2000; Richardson et al., 2008). 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