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Clinical effect (difference of 1.3 to 2.5 points) observed in all symptoms for patients with moderate/severe symptoms between baseline and FUP1; however, there was no clinical effect for patients with mild symptoms (from − 0.3 to − 1.8) (Fig. 2). The maximum THC dose recorded at FUP1 (90 mg) was prescribed for two patients for the treatment of pain. The maximum initial CBD dose recorded (156 mg) was prescribed for the treatment of pain of one patient. We strive to provide high-quality products for our customers, and we're glad that you are happy with your purchase. We always strive to provide top-quality products for our customers. All effects are not known due to limited or no short term or long term studies on the effects of the cannabinoids or the products created with them. CBD gummies should be taken as any other gummy, no matter your health condition. Furthermore, taking CBD gummies every night will build a tolerance – so, you may need to take more in order to feel the effects. 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